Crystal structure of Lymnaea stagnalis AChBP complexed with the potent nAChR antagonist DHβE suggests a unique mode of antagonism.

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed), activated (open), and desensitized (closed) states....

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Auteurs principaux: Azadeh Shahsavar, Jette S Kastrup, Elsebet Ø Nielsen, Jesper L Kristensen, Michael Gajhede, Thomas Balle
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2012
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R
Q
Accès en ligne:https://doaj.org/article/115e919b246f4698b2139f81c7b8006a
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