Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells

Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells

Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-XL preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune res...

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Autores principales: Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/11696984783a45a99be93e6ba397acf8
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spelling oai:doaj.org-article:11696984783a45a99be93e6ba397acf82021-12-02T13:14:47ZProteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells10.1038/s41467-021-21573-x2041-1723https://doaj.org/article/11696984783a45a99be93e6ba397acf82021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21573-xhttps://doaj.org/toc/2041-1723Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-XL preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune responses in preclinical cancer models.Ryan KolbUmasankar DeSajid KhanYuewan LuoMyung-Chul KimHaijun YuChaoyan WuJiao MoXin ZhangPeiyi ZhangXuan ZhangNicholas BorcherdingDaniel KoppelYang-Xin FuSong Guo ZhengDorina AvramGuangrong ZhengDaohong ZhouWeizhou ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ryan Kolb
Umasankar De
Sajid Khan
Yuewan Luo
Myung-Chul Kim
Haijun Yu
Chaoyan Wu
Jiao Mo
Xin Zhang
Peiyi Zhang
Xuan Zhang
Nicholas Borcherding
Daniel Koppel
Yang-Xin Fu
Song Guo Zheng
Dorina Avram
Guangrong Zheng
Daohong Zhou
Weizhou Zhang
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
description Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-XL preferentially induces apoptosis of tumor-infiltrating Treg, promoting CD8 T cell activation and anti-tumor immune responses in preclinical cancer models.
format article
author Ryan Kolb
Umasankar De
Sajid Khan
Yuewan Luo
Myung-Chul Kim
Haijun Yu
Chaoyan Wu
Jiao Mo
Xin Zhang
Peiyi Zhang
Xuan Zhang
Nicholas Borcherding
Daniel Koppel
Yang-Xin Fu
Song Guo Zheng
Dorina Avram
Guangrong Zheng
Daohong Zhou
Weizhou Zhang
author_facet Ryan Kolb
Umasankar De
Sajid Khan
Yuewan Luo
Myung-Chul Kim
Haijun Yu
Chaoyan Wu
Jiao Mo
Xin Zhang
Peiyi Zhang
Xuan Zhang
Nicholas Borcherding
Daniel Koppel
Yang-Xin Fu
Song Guo Zheng
Dorina Avram
Guangrong Zheng
Daohong Zhou
Weizhou Zhang
author_sort Ryan Kolb
title Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
title_short Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
title_full Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
title_fullStr Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
title_full_unstemmed Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
title_sort proteolysis-targeting chimera against bcl-xl destroys tumor-infiltrating regulatory t cells
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/11696984783a45a99be93e6ba397acf8
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