Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.

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Autores principales:	Åsa Ehlén, Charlotte Martin, Simona Miron, Manon Julien, François-Xavier Theillet, Virginie Ropars, Gaetana Sessa, Romane Beaurepere, Virginie Boucherit, Patricia Duchambon, Ahmed El Marjou, Sophie Zinn-Justin, Aura Carreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1172298aed5c403d86de4c53b25b80bd
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spelling	oai:doaj.org-article:1172298aed5c403d86de4c53b25b80bd2021-12-02T17:32:57ZProper chromosome alignment depends on BRCA2 phosphorylation by PLK110.1038/s41467-020-15689-92041-1723https://doaj.org/article/1172298aed5c403d86de4c53b25b80bd2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15689-9https://doaj.org/toc/2041-1723The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.Åsa EhlénCharlotte MartinSimona MironManon JulienFrançois-Xavier TheilletVirginie RoparsGaetana SessaRomane BeaurepereVirginie BoucheritPatricia DuchambonAhmed El MarjouSophie Zinn-JustinAura CarreiraNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Åsa Ehlén Charlotte Martin Simona Miron Manon Julien François-Xavier Theillet Virginie Ropars Gaetana Sessa Romane Beaurepere Virginie Boucherit Patricia Duchambon Ahmed El Marjou Sophie Zinn-Justin Aura Carreira Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
description	The BRCA2 tumour suppressor protein is known to play an important role in homologous recombination. Here the authors reveal how the phosphorylation of BRCA2 by Polo-like kinase 1 (PLK1) contributes to the regulation of mitosis.
format	article
author	Åsa Ehlén Charlotte Martin Simona Miron Manon Julien François-Xavier Theillet Virginie Ropars Gaetana Sessa Romane Beaurepere Virginie Boucherit Patricia Duchambon Ahmed El Marjou Sophie Zinn-Justin Aura Carreira
author_facet	Åsa Ehlén Charlotte Martin Simona Miron Manon Julien François-Xavier Theillet Virginie Ropars Gaetana Sessa Romane Beaurepere Virginie Boucherit Patricia Duchambon Ahmed El Marjou Sophie Zinn-Justin Aura Carreira
author_sort	Åsa Ehlén
title	Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
title_short	Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
title_full	Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
title_fullStr	Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
title_full_unstemmed	Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
title_sort	proper chromosome alignment depends on brca2 phosphorylation by plk1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1172298aed5c403d86de4c53b25b80bd
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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

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