Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

Lochocki et al. report detection of amyloid plaques by label-free fluorescence and Raman imaging in snap-frozen frontal cortex tissue from Alzheimer’s disease cases. They identify presence of carotenoid in a cored amyloid plaque area, versus a non-plaque area, suggesting a distinct neuroinflammatory...

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Autores principales:	Benjamin Lochocki, Baayla D. C. Boon, Sander R. Verheul, Liron Zada, Jeroen J. M. Hoozemans, Freek Ariese, Johannes F. de Boer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/117dde8786184e2c8fb9f7c360ba1851
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spelling	oai:doaj.org-article:117dde8786184e2c8fb9f7c360ba18512021-12-02T14:30:33ZMultimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue10.1038/s42003-021-01981-x2399-3642https://doaj.org/article/117dde8786184e2c8fb9f7c360ba18512021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01981-xhttps://doaj.org/toc/2399-3642Lochocki et al. report detection of amyloid plaques by label-free fluorescence and Raman imaging in snap-frozen frontal cortex tissue from Alzheimer’s disease cases. They identify presence of carotenoid in a cored amyloid plaque area, versus a non-plaque area, suggesting a distinct neuroinflammatory response to misfolded protein aggregations.Benjamin LochockiBaayla D. C. BoonSander R. VerheulLiron ZadaJeroen J. M. HoozemansFreek ArieseJohannes F. de BoerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Benjamin Lochocki Baayla D. C. Boon Sander R. Verheul Liron Zada Jeroen J. M. Hoozemans Freek Ariese Johannes F. de Boer Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
description	Lochocki et al. report detection of amyloid plaques by label-free fluorescence and Raman imaging in snap-frozen frontal cortex tissue from Alzheimer’s disease cases. They identify presence of carotenoid in a cored amyloid plaque area, versus a non-plaque area, suggesting a distinct neuroinflammatory response to misfolded protein aggregations.
format	article
author	Benjamin Lochocki Baayla D. C. Boon Sander R. Verheul Liron Zada Jeroen J. M. Hoozemans Freek Ariese Johannes F. de Boer
author_facet	Benjamin Lochocki Baayla D. C. Boon Sander R. Verheul Liron Zada Jeroen J. M. Hoozemans Freek Ariese Johannes F. de Boer
author_sort	Benjamin Lochocki
title	Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
title_short	Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
title_full	Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
title_fullStr	Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
title_full_unstemmed	Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue
title_sort	multimodal, label-free fluorescence and raman imaging of amyloid deposits in snap-frozen alzheimer’s disease human brain tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/117dde8786184e2c8fb9f7c360ba1851
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Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer’s disease human brain tissue

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