Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli

Curli amyloid fibers are important components of bacterial biofilms formed by E. coli and Salmonella. Here, Tursi et al. show that a human monoclonal antibody with pan-amyloid binding activity can disrupt biofilms formed by Salmonella Typhimurium in vitro and in vivo.

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Autores principales:	Sarah A. Tursi, Rama Devudu Puligedda, Paul Szabo, Lauren K. Nicastro, Amanda L. Miller, Connie Qiu, Stefania Gallucci, Norman R. Relkin, Bettina A. Buttaro, Scott K. Dessain, Çagla Tükel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11897af34d794b4a87d6cb813eff5536
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spelling	oai:doaj.org-article:11897af34d794b4a87d6cb813eff55362021-12-02T14:40:40ZSalmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli10.1038/s41467-020-14685-32041-1723https://doaj.org/article/11897af34d794b4a87d6cb813eff55362020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14685-3https://doaj.org/toc/2041-1723Curli amyloid fibers are important components of bacterial biofilms formed by E. coli and Salmonella. Here, Tursi et al. show that a human monoclonal antibody with pan-amyloid binding activity can disrupt biofilms formed by Salmonella Typhimurium in vitro and in vivo.Sarah A. TursiRama Devudu PuligeddaPaul SzaboLauren K. NicastroAmanda L. MillerConnie QiuStefania GallucciNorman R. RelkinBettina A. ButtaroScott K. DessainÇagla TükelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah A. Tursi Rama Devudu Puligedda Paul Szabo Lauren K. Nicastro Amanda L. Miller Connie Qiu Stefania Gallucci Norman R. Relkin Bettina A. Buttaro Scott K. Dessain Çagla Tükel Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
description	Curli amyloid fibers are important components of bacterial biofilms formed by E. coli and Salmonella. Here, Tursi et al. show that a human monoclonal antibody with pan-amyloid binding activity can disrupt biofilms formed by Salmonella Typhimurium in vitro and in vivo.
format	article
author	Sarah A. Tursi Rama Devudu Puligedda Paul Szabo Lauren K. Nicastro Amanda L. Miller Connie Qiu Stefania Gallucci Norman R. Relkin Bettina A. Buttaro Scott K. Dessain Çagla Tükel
author_facet	Sarah A. Tursi Rama Devudu Puligedda Paul Szabo Lauren K. Nicastro Amanda L. Miller Connie Qiu Stefania Gallucci Norman R. Relkin Bettina A. Buttaro Scott K. Dessain Çagla Tükel
author_sort	Sarah A. Tursi
title	Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
title_short	Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
title_full	Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
title_fullStr	Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
title_full_unstemmed	Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
title_sort	salmonella typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/11897af34d794b4a87d6cb813eff5536
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Salmonella Typhimurium biofilm disruption by a human antibody that binds a pan-amyloid epitope on curli

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