A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells

A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells

Abstract Cigarette smoke (CS) exposure is one of the primary risk factors associated with the chronic mucous hypersecretion (CMH). The antiapoptotic protein, Bcl-2 sustains hyperplastic mucous cells, and the airway epithelium of ex-smokers with CMH as well as mice exposed to chronic CS showed increa...

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Autores principales: Shah S. Hussain, Shebin George, Shashi Singh, Rahul Jayant, Chien-An Hu, Mohan Sopori, Hitendra S. Chand
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Airway Epithelial Cells (AECs)
MUC1 Expression
Epithelial Growth Factor Receptor (EGFR)
Extracellular-signal Regulating Kinase 1/2 (ERK1/2)
Human AECs
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/118db596e69245a78848a2480a554f26
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https://doaj.org/article/118db596e69245a78848a2480a554f26

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