Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain

Summary: Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing NTD-directed antibodies have been studied structurally, and all target a single antigenic supersite in NTD (site 1). Here, we report th...

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Autores principales: Gabriele Cerutti, Yicheng Guo, Pengfei Wang, Manoj S. Nair, Maple Wang, Yaoxing Huang, Jian Yu, Lihong Liu, Phinikoula S. Katsamba, Fabiana Bahna, Eswar R. Reddem, Peter D. Kwong, David D. Ho, Zizhang Sheng, Lawrence Shapiro
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
COVID-19
cryo-EM
neutralizing antibody
N-terminal domain
NTD
antigenic supersite
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/119804b01c4646e6825cbbdee4f5658b
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https://doaj.org/article/119804b01c4646e6825cbbdee4f5658b

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