Designing antifilarial drug trials using clinical trial simulators

Drugs for filariases are under development and clinical trial simulators could help to inform the design of clinical trials. Here, Walker et al. use an individual-based onchocerciasis transmission model to project trial outcomes of a hypothetical macrofilaricidal drug, resolving key design choices.

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Autores principales:	Martin Walker, Jonathan I. D. Hamley, Philip Milton, Frédéric Monnot, Belén Pedrique, Maria-Gloria Basáñez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/11d40320cabe405db511497a47479856
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spelling	oai:doaj.org-article:11d40320cabe405db511497a474798562021-12-02T15:03:12ZDesigning antifilarial drug trials using clinical trial simulators10.1038/s41467-020-16442-y2041-1723https://doaj.org/article/11d40320cabe405db511497a474798562020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16442-yhttps://doaj.org/toc/2041-1723Drugs for filariases are under development and clinical trial simulators could help to inform the design of clinical trials. Here, Walker et al. use an individual-based onchocerciasis transmission model to project trial outcomes of a hypothetical macrofilaricidal drug, resolving key design choices.Martin WalkerJonathan I. D. HamleyPhilip MiltonFrédéric MonnotBelén PedriqueMaria-Gloria BasáñezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Walker Jonathan I. D. Hamley Philip Milton Frédéric Monnot Belén Pedrique Maria-Gloria Basáñez Designing antifilarial drug trials using clinical trial simulators
description	Drugs for filariases are under development and clinical trial simulators could help to inform the design of clinical trials. Here, Walker et al. use an individual-based onchocerciasis transmission model to project trial outcomes of a hypothetical macrofilaricidal drug, resolving key design choices.
format	article
author	Martin Walker Jonathan I. D. Hamley Philip Milton Frédéric Monnot Belén Pedrique Maria-Gloria Basáñez
author_facet	Martin Walker Jonathan I. D. Hamley Philip Milton Frédéric Monnot Belén Pedrique Maria-Gloria Basáñez
author_sort	Martin Walker
title	Designing antifilarial drug trials using clinical trial simulators
title_short	Designing antifilarial drug trials using clinical trial simulators
title_full	Designing antifilarial drug trials using clinical trial simulators
title_fullStr	Designing antifilarial drug trials using clinical trial simulators
title_full_unstemmed	Designing antifilarial drug trials using clinical trial simulators
title_sort	designing antifilarial drug trials using clinical trial simulators
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/11d40320cabe405db511497a47479856
work_keys_str_mv	AT martinwalker designingantifilarialdrugtrialsusingclinicaltrialsimulators AT jonathanidhamley designingantifilarialdrugtrialsusingclinicaltrialsimulators AT philipmilton designingantifilarialdrugtrialsusingclinicaltrialsimulators AT fredericmonnot designingantifilarialdrugtrialsusingclinicaltrialsimulators AT belenpedrique designingantifilarialdrugtrialsusingclinicaltrialsimulators AT mariagloriabasanez designingantifilarialdrugtrialsusingclinicaltrialsimulators
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Designing antifilarial drug trials using clinical trial simulators

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