Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of t...

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Main Authors: Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, Christian C. Gruber, Karl Gruber, David Haselbach, Helmut Bergler
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3
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https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3

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