The Interface between Cell Signaling Pathways and Pregnane X Receptor

The Interface between Cell Signaling Pathways and Pregnane X Receptor

Highly expressed in the enterohepatic system, pregnane X receptor (PXR, NR1I2) is a well-characterized nuclear receptor (NR) that regulates the expression of genes in the liver and intestines that encode key drug metabolizing enzymes and drug transporter proteins in mammals. The net effect of PXR ac...

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Autores principales: Robert S. Rogers, Annemarie Parker, Phill D. Vainer, Elijah Elliott, Dakota Sudbeck, Kaushal Parimi, Venkata P. Peddada, Parker G. Howe, Nick D’Ambrosio, Gregory Ruddy, Kaitlin Stackable, Megan Carney, Lauren Martin, Thomas Osterholt, Jeff L. Staudinger
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
nuclear receptor
pregnane X receptor
xenobiotics
cell signaling
phosphorylation
SUMOylation
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/12300440a91a4307ae823bbd7287c260
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https://doaj.org/article/12300440a91a4307ae823bbd7287c260

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