Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution

Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging. Here the authors develop a FRAP-based super-resolution microscopy method to obtain this inform...

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Autores principales:	Krishna C Mudumbi, Eric C Schirmer, Weidong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12654410bba34692906c4ecb63070f9b
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spelling	oai:doaj.org-article:12654410bba34692906c4ecb63070f9b2021-12-02T14:38:35ZSingle-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution10.1038/ncomms125622041-1723https://doaj.org/article/12654410bba34692906c4ecb63070f9b2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12562https://doaj.org/toc/2041-1723Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging. Here the authors develop a FRAP-based super-resolution microscopy method to obtain this information for several NETs.Krishna C MudumbiEric C SchirmerWeidong YangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Krishna C Mudumbi Eric C Schirmer Weidong Yang Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
description	Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging. Here the authors develop a FRAP-based super-resolution microscopy method to obtain this information for several NETs.
format	article
author	Krishna C Mudumbi Eric C Schirmer Weidong Yang
author_facet	Krishna C Mudumbi Eric C Schirmer Weidong Yang
author_sort	Krishna C Mudumbi
title	Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
title_short	Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
title_full	Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
title_fullStr	Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
title_full_unstemmed	Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution
title_sort	single-point single-molecule frap distinguishes inner and outer nuclear membrane protein distribution
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/12654410bba34692906c4ecb63070f9b
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Single-point single-molecule FRAP distinguishes inner and outer nuclear membrane protein distribution

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