Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop

In order to assist the development of cancer stem cell (CSC) therapy, Kim et al identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells. They demonstrated in cancer cell lines and in vivo that TSPYL5 activity is depend...

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Autores principales: In-Gyu Kim, Jei-Ha Lee, Seo-Yeon Kim, Chang-Kyu Heo, Rae-Kwon Kim, Eun-Wie Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/12adcf87e5ab49d3bc333e7ba19e9619
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