Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop

In order to assist the development of cancer stem cell (CSC) therapy, Kim et al identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells. They demonstrated in cancer cell lines and in vivo that TSPYL5 activity is depend...

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Autores principales:	In-Gyu Kim, Jei-Ha Lee, Seo-Yeon Kim, Chang-Kyu Heo, Rae-Kwon Kim, Eun-Wie Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/12adcf87e5ab49d3bc333e7ba19e9619
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spelling	oai:doaj.org-article:12adcf87e5ab49d3bc333e7ba19e96192021-12-02T17:14:23ZTargeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop10.1038/s42003-021-02303-x2399-3642https://doaj.org/article/12adcf87e5ab49d3bc333e7ba19e96192021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02303-xhttps://doaj.org/toc/2399-3642In order to assist the development of cancer stem cell (CSC) therapy, Kim et al identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells. They demonstrated in cancer cell lines and in vivo that TSPYL5 activity is dependent on AKT signalling and that disruption of TSPYL5 signalling could serve as a potential strategy to tackle therapy-resistant cancers.In-Gyu KimJei-Ha LeeSeo-Yeon KimChang-Kyu HeoRae-Kwon KimEun-Wie ChoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 In-Gyu Kim Jei-Ha Lee Seo-Yeon Kim Chang-Kyu Heo Rae-Kwon Kim Eun-Wie Cho Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
description	In order to assist the development of cancer stem cell (CSC) therapy, Kim et al identified testis-specific Y-like protein 5 (TSPYL5) as an upstream regulator of CSC-associated genes in non-small cell lung cancer cells. They demonstrated in cancer cell lines and in vivo that TSPYL5 activity is dependent on AKT signalling and that disruption of TSPYL5 signalling could serve as a potential strategy to tackle therapy-resistant cancers.
format	article
author	In-Gyu Kim Jei-Ha Lee Seo-Yeon Kim Chang-Kyu Heo Rae-Kwon Kim Eun-Wie Cho
author_facet	In-Gyu Kim Jei-Ha Lee Seo-Yeon Kim Chang-Kyu Heo Rae-Kwon Kim Eun-Wie Cho
author_sort	In-Gyu Kim
title	Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
title_short	Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
title_full	Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
title_fullStr	Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
title_full_unstemmed	Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop
title_sort	targeting therapy-resistant lung cancer stem cells via disruption of the akt/tspyl5/pten positive-feedback loop
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12adcf87e5ab49d3bc333e7ba19e9619
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Targeting therapy-resistant lung cancer stem cells via disruption of the AKT/TSPYL5/PTEN positive-feedback loop

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