Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.

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Autores principales:	Wenya Tian, Chenghai Sun, Mei Zheng, Jeffrey R. Harmer, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Zixin Deng, Shi-Lu Chen, Mehdi Mobli, Xinying Jia, Xudong Qu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12b77cd5819e4944a3c13f7f3c161693
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spelling	oai:doaj.org-article:12b77cd5819e4944a3c13f7f3c1616932021-12-02T14:40:04ZEfficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids10.1038/s41467-018-06528-z2041-1723https://doaj.org/article/12b77cd5819e4944a3c13f7f3c1616932018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06528-zhttps://doaj.org/toc/2041-1723The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.Wenya TianChenghai SunMei ZhengJeffrey R. HarmerMingjia YuYanan ZhangHaidong PengDongqing ZhuZixin DengShi-Lu ChenMehdi MobliXinying JiaXudong QuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenya Tian Chenghai Sun Mei Zheng Jeffrey R. Harmer Mingjia Yu Yanan Zhang Haidong Peng Dongqing Zhu Zixin Deng Shi-Lu Chen Mehdi Mobli Xinying Jia Xudong Qu Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
description	The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.
format	article
author	Wenya Tian Chenghai Sun Mei Zheng Jeffrey R. Harmer Mingjia Yu Yanan Zhang Haidong Peng Dongqing Zhu Zixin Deng Shi-Lu Chen Mehdi Mobli Xinying Jia Xudong Qu
author_facet	Wenya Tian Chenghai Sun Mei Zheng Jeffrey R. Harmer Mingjia Yu Yanan Zhang Haidong Peng Dongqing Zhu Zixin Deng Shi-Lu Chen Mehdi Mobli Xinying Jia Xudong Qu
author_sort	Wenya Tian
title	Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
title_short	Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
title_full	Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
title_fullStr	Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
title_full_unstemmed	Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids
title_sort	efficient biosynthesis of heterodimeric c3-aryl pyrroloindoline alkaloids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/12b77cd5819e4944a3c13f7f3c161693
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Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

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