Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease

Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease

Abstract Recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities of α-synuclein (ASYN) in neurodegenerative disease such as familial Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease. Using a transgenic mouse model...

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Bibliographic Details
Main Authors: Fang Fang, Wanlin Yang, Jazmin B. Florio, Edward Rockenstein, Brian Spencer, Xavier M. Orain, Stephanie X. Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A. Rissman, Eliezer Masliah, Jianqing Ding, Chengbiao Wu
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/12c01bf2810f488c9d8ecb8510422e17
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https://doaj.org/article/12c01bf2810f488c9d8ecb8510422e17

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