Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson’s disease
Abstract Recent studies have demonstrated that hyperphosphorylation of tau protein plays a role in neuronal toxicities of α-synuclein (ASYN) in neurodegenerative disease such as familial Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and Parkinson’s disease. Using a transgenic mouse model...
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Autores principales: | Fang Fang, Wanlin Yang, Jazmin B. Florio, Edward Rockenstein, Brian Spencer, Xavier M. Orain, Stephanie X. Dong, Huayan Li, Xuqiao Chen, Kijung Sung, Robert A. Rissman, Eliezer Masliah, Jianqing Ding, Chengbiao Wu |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/12c01bf2810f488c9d8ecb8510422e17 |
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