The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidne...

Full description

Saved in:
Bibliographic Details
Main Authors: Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/12c73f6333324432b9f2c84850631506
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/12c73f6333324432b9f2c84850631506

Similar Items