The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidne...

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Autores principales:	Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12c73f6333324432b9f2c84850631506
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spelling	oai:doaj.org-article:12c73f6333324432b9f2c848506315062021-12-02T15:02:47ZThe ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion10.1038/s41467-020-16525-w2041-1723https://doaj.org/article/12c73f6333324432b9f2c848506315062020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16525-whttps://doaj.org/toc/2041-1723The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.Kazi Mirajul HoqueEryn E. DixonRaychel M. LewisJordyn AllanGregory D. GambleAmanda J. Phipps-GreenVictoria L. Halperin KuhnsAnne M. HorneLisa K. StampTony R. MerrimanNicola DalbethOwen M. WoodwardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kazi Mirajul Hoque Eryn E. Dixon Raychel M. Lewis Jordyn Allan Gregory D. Gamble Amanda J. Phipps-Green Victoria L. Halperin Kuhns Anne M. Horne Lisa K. Stamp Tony R. Merriman Nicola Dalbeth Owen M. Woodward The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
description	The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.
format	article
author	Kazi Mirajul Hoque Eryn E. Dixon Raychel M. Lewis Jordyn Allan Gregory D. Gamble Amanda J. Phipps-Green Victoria L. Halperin Kuhns Anne M. Horne Lisa K. Stamp Tony R. Merriman Nicola Dalbeth Owen M. Woodward
author_facet	Kazi Mirajul Hoque Eryn E. Dixon Raychel M. Lewis Jordyn Allan Gregory D. Gamble Amanda J. Phipps-Green Victoria L. Halperin Kuhns Anne M. Horne Lisa K. Stamp Tony R. Merriman Nicola Dalbeth Owen M. Woodward
author_sort	Kazi Mirajul Hoque
title	The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
title_short	The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
title_full	The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
title_fullStr	The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
title_full_unstemmed	The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
title_sort	abcg2 q141k hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/12c73f6333324432b9f2c84850631506
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The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

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