Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor

Summary: Myeloid-derived suppressor cells (MDSCs) enhance the proliferation of endothelial cells to stimulate angiogenesis. However, many aggressive malignant tumors do not have endothelial cell-dependent blood vessels in the early stage and instead generate microcirculation by forming vasculogenic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yinan Li, Kailiang Qiao, Xiaoyun Zhang, Haoyang Liu, Heng Zhang, Zhiyang Li, Yanrong Liu, Tao Sun
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cancer Genetics Science Q
Acceso en línea:	https://doaj.org/article/12d4e99362da4897a3f0cb8d90ba9f52
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:12d4e99362da4897a3f0cb8d90ba9f52
record_format	dspace
spelling	oai:doaj.org-article:12d4e99362da4897a3f0cb8d90ba9f522021-11-18T04:51:15ZTargeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor2589-004210.1016/j.isci.2021.103392https://doaj.org/article/12d4e99362da4897a3f0cb8d90ba9f522021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013638https://doaj.org/toc/2589-0042Summary: Myeloid-derived suppressor cells (MDSCs) enhance the proliferation of endothelial cells to stimulate angiogenesis. However, many aggressive malignant tumors do not have endothelial cell-dependent blood vessels in the early stage and instead generate microcirculation by forming vasculogenic mimicry (VM). To date, the relationship between MDSCs and tumor cells remains the focus of ongoing studies. In this work, MDSCs were co-cultured with mouse melanoma cells and can enhance proliferation and VM formation of melanoma cells. For MDSCs targeting, doxycycline (DOX) was found to selectively suppress PMN-MDSCs but has no influence on T cells. In addition, DOX pretreatment substantially reduced the promoting ability of MDSCs for the VM formation of B16-F10 cells. DOX also inhibited tumor growth and enhanced the antitumor activity of PD-1 inhibitors in C57BL6 and BALB/c mice subcutaneously inoculated with B16-F10 and 4T1 cells, respectively. In conclusion, the combination of DOX and PD-1 inhibitor could be an anticancer strategy.Yinan LiKailiang QiaoXiaoyun ZhangHaoyang LiuHeng ZhangZhiyang LiYanrong LiuTao SunElsevierarticleCancerGeneticsScienceQENiScience, Vol 24, Iss 12, Pp 103392- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cancer Genetics Science Q
spellingShingle	Cancer Genetics Science Q Yinan Li Kailiang Qiao Xiaoyun Zhang Haoyang Liu Heng Zhang Zhiyang Li Yanrong Liu Tao Sun Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
description	Summary: Myeloid-derived suppressor cells (MDSCs) enhance the proliferation of endothelial cells to stimulate angiogenesis. However, many aggressive malignant tumors do not have endothelial cell-dependent blood vessels in the early stage and instead generate microcirculation by forming vasculogenic mimicry (VM). To date, the relationship between MDSCs and tumor cells remains the focus of ongoing studies. In this work, MDSCs were co-cultured with mouse melanoma cells and can enhance proliferation and VM formation of melanoma cells. For MDSCs targeting, doxycycline (DOX) was found to selectively suppress PMN-MDSCs but has no influence on T cells. In addition, DOX pretreatment substantially reduced the promoting ability of MDSCs for the VM formation of B16-F10 cells. DOX also inhibited tumor growth and enhanced the antitumor activity of PD-1 inhibitors in C57BL6 and BALB/c mice subcutaneously inoculated with B16-F10 and 4T1 cells, respectively. In conclusion, the combination of DOX and PD-1 inhibitor could be an anticancer strategy.
format	article
author	Yinan Li Kailiang Qiao Xiaoyun Zhang Haoyang Liu Heng Zhang Zhiyang Li Yanrong Liu Tao Sun
author_facet	Yinan Li Kailiang Qiao Xiaoyun Zhang Haoyang Liu Heng Zhang Zhiyang Li Yanrong Liu Tao Sun
author_sort	Yinan Li
title	Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
title_short	Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
title_full	Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
title_fullStr	Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
title_full_unstemmed	Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
title_sort	targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of pd-1 inhibitor
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/12d4e99362da4897a3f0cb8d90ba9f52
work_keys_str_mv	AT yinanli targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT kailiangqiao targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT xiaoyunzhang targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT haoyangliu targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT hengzhang targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT zhiyangli targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT yanrongliu targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor AT taosun targetingmyeloidderivedsuppressorcellstoattenuatevasculogenicmimicryandsynergisticallyenhancetheantitumoreffectofpd1inhibitor
_version_	1718424957865689088

Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor

Ejemplares similares