Artemisinin Binds and Inhibits the Activity of <i>Plasmodium falciparum</i> Ddi1, a Retroviral Aspartyl Protease

Código QR

Artemisinin Binds and Inhibits the Activity of <i>Plasmodium falciparum</i> Ddi1, a Retroviral Aspartyl Protease

Reduced sensitivity of the human malaria parasite, <i>Plasmodium falciparum,</i> to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic insults, which results in the activation of t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Noah Machuki Onchieku, Sonam Kumari, Rajan Pandey, Vaibhav Sharma, Mohit Kumar, Arunaditya Deshmukh, Inderjeet Kaur, Asif Mohmmed, Dinesh Gupta, Daniel Kiboi, Naseem Gaur, Pawan Malhotra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	artemisinin <i>Plasmodium falciparum</i> DNA damage Ddi1 ubiquitin-proteasome pathway enzyme inhibition Medicine R
Acceso en línea:	https://doaj.org/article/12dac69b553b417182b3d7f7b001afec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

In Vitro Adventitious Regeneration of <i>Artemisia annua</i> L. Influencing Artemisinin Metabolism
por: Federica Blando, et al.
Publicado: (2021)

Studies of Potency and Efficacy of an Optimized Artemisinin-Quinoline Hybrid against Multiple Stages of the <i>Plasmodium</i> Life Cycle
por: Helenita C. Quadros, et al.
Publicado: (2021)

On the Role of the Immunoproteasome in Protein Homeostasis
por: Michael Basler, et al.
Publicado: (2021)

Regulation of cell polarity by controlled proteolytic systems
por: Bórquez,Daniel A, et al.
Publicado: (2011)

Anti-Multiple Myeloma Potential of Secondary Metabolites from <i>Hibiscus sabdariffa</i>—Part 2
por: Alessio Malacrida, et al.
Publicado: (2021)

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
por: Anmol Sharma, et al.
Publicado: (2021)

Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
por: Samuel B. Anyona, et al.
Publicado: (2021)

More Than Just Cleaning: Ubiquitin-Mediated Proteolysis in Fungal Pathogenesis
por: Chengjun Cao, et al.
Publicado: (2021)

A Z-Linked E3 Ubiquitin Ligase <i>Cs-rchy1</i> Is Involved in Gametogenesis in Chinese Tongue Sole, <i>Cynoglossus semilaevis</i>
por: Yuxuan Sun, et al.
Publicado: (2021)

Investigation of the Effects of Artemisinin on Testis and Kidney Injury Induced by Doxorubicin
por: Tutun Hidayet, et al.
Publicado: (2019)

Proteasome Inhibition Is an Effective Treatment Strategy for Microsporidia Infection in Honey Bees
por: Emily M. Huntsman, et al.
Publicado: (2021)

Nanoliposomal artemisinin for the treatment of murine visceral leishmaniasis
por: Want MY, et al.
Publicado: (2017)

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions
por: Aixin Song, et al.
Publicado: (2021)

A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes
por: Alexander Burov, et al.
Publicado: (2021)

The Biological Function and Roles in Phytohormone Signaling of the F-Box Protein in Plants
por: Keheng Xu, et al.
Publicado: (2021)

Molecular and Functional Analysis of U-box E3 Ubiquitin Ligase Gene Family in Rice (<i>Oryza</i> <i>sativa</i>)
por: Me-Sun Kim, et al.
Publicado: (2021)

Development of a Multiplex Droplet Digital PCR Assay for the Detection of <i>Babesia</i>, <i>Bartonella</i>, and <i>Borrelia</i> Species
por: Ricardo Maggi, et al.
Publicado: (2021)

Insights into the Evolution of Spermatogenesis-Related Ubiquitin–Proteasome System Genes in Abdominal Testicular Laurasiatherians
por: Xiaoyue Ding, et al.
Publicado: (2021)

(<i>L</i>,⊙)-Fuzzy (<i>K</i>,<i>E</i>)-Soft Filter
por: Ahmed Aref Abd El-Latif, et al.
Publicado: (2021)

Comparison of the Scorpionism Caused by <i>Centruroides</i> <i>margaritatus</i>, <i>Tityus</i> <i>pachyurus</i> and <i>Tityus</i> n. sp. aff. <i>metuendus</i> Scorpion Venoms in Colombia
por: Leydy Lorena Mendoza-Tobar, et al.
Publicado: (2021)

<i>C</i>*-Algebra Valued Modular <i>G</i>-Metric Spaces with Applications in Fixed Point Theory
por: Dipankar Das, et al.
Publicado: (2021)

The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins
por: Austin Folger, et al.
Publicado: (2021)

A Journey from June 2018 to October 2021 with <i>N</i>,<i>N</i>-Dimethylformamide and <i>N</i>,<i>N</i>-Dimethylacetamide as Reactants
por: Jacques Muzart
Publicado: (2021)

<i>f</i>(<i>T</i>, <i>B</i>) Cosmography for High Redshifts
por: Celia Escamilla-Rivera, et al.
Publicado: (2021)

Seaweed Extract-Stimulated Priming in <i>Arabidopsis thaliana</i> and <i>Solanum lycopersicum</i>
por: Md Tohidul Islam, et al.
Publicado: (2021)

Separate Fractional (<i>p</i>,<i>q</i>)-Integrodifference Equations via Nonlocal Fractional (<i>p</i>,<i>q</i>)-Integral Boundary Conditions
por: Thongchai Dumrongpokaphan, et al.
Publicado: (2021)

Development of Various <i>Leishmania</i> (<i>Sauroleishmania</i>) <i>tarentolae</i> Strains in Three <i>Phlebotomus</i> Species
por: Lucie Ticha, et al.
Publicado: (2021)

Absence of Plasmodium falciparum artemisinin resistance gene mutations eleven years after the adoption of artemisinin-based combination therapy in Nigeria
por: Moses Ikegbunam, et al.
Publicado: (2021)

Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss
por: Li X, et al.
Publicado: (2020)

Mycosubtilin Produced by <i>Bacillus subtilis</i> ATCC6633 Inhibits Growth and Mycotoxin Biosynthesis of <i>Fusarium graminearum</i> and <i>Fusarium verticillioides</i>
por: Chenjie Yu, et al.
Publicado: (2021)

The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
por: Claire Bonsergent, et al.
Publicado: (2021)

Proteolysis-targeting chimeras and their implications in breast cancer
por: Angeles C. Tecalco-Cruz, et al.
Publicado: (2021)

Effectivity Of Annona Muricata and Artemisinin Combined Therapy on Brain CXCL10 expression (Study in Swiss Mice During Severe Plasmodium Berghei ANKA Infection)
por: Abdulhakim Sulayman, et al.
Publicado: (2019)

Role of <i>Sesamia nonagrioides</i> and <i>Ostrinia nubilalis</i> as Vectors of <i>Fusarium</i> spp. and Contribution of Corn Borer-Resistant Bt Maize to Mycotoxin Reduction
por: María Arias-Martín, et al.
Publicado: (2021)

<i>k</i>-Zero-Divisor and Ideal-Based <i>k</i>-Zero-Divisor Hypergraphs of Some Commutative Rings
por: Pinkaew Siriwong, et al.
Publicado: (2021)

Expression Patterns of miR398, miR167, and miR159 in the Interaction between Bread Wheat (<i>Triticum</i> <i>aestivum</i> L.) and Pathogenic <i>Fusarium</i> <i>culmorum</i> and Beneficial <i>Trichoderma</i> Fungi
por: Sylwia Salamon, et al.
Publicado: (2021)

Establishment of a Novel and Efficient <i>Agrobacterium</i>-Mediated <i>in Planta</i> Transformation System for Passion Fruit (<i>Passiflora edulis</i>)
por: Hafiz Muhammad Rizwan, et al.
Publicado: (2021)

Production of Genistein in <i>Amaranthus tricolor</i> var. <i>tristis</i> and <i>Spinacia oleracea</i> by Expression of <i>Glycine max Isoflavone Synthase</i>
por: Ashwini Malla, et al.
Publicado: (2021)

Removal of Flotation Collector <i>O</i>-Isopropyl-<i>N</i>-ethylthionocarbamate from Wastewater
por: Zhe Wang, et al.
Publicado: (2021)

Mycorrhizal Compatibility and Germination-Promoting Activity of <i>Tulasnella</i> Species in Two Species of Orchid (<i>Cymbidium mannii</i> and <i>Epidendrum radicans</i>)
por: Qianyu Yang, et al.
Publicado: (2021)