MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity.

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Autores principales: Derek J. C. Tai, Yen C. Liu, Wei L. Hsu, Yun L. Ma, Sin J. Cheng, Shau Y. Liu, Eminy H. Y. Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/12ecdd0778e649b788738dc5fc934974
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