MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity.

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Autores principales:	Derek J. C. Tai, Yen C. Liu, Wei L. Hsu, Yun L. Ma, Sin J. Cheng, Shau Y. Liu, Eminy H. Y. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12ecdd0778e649b788738dc5fc934974
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spelling	oai:doaj.org-article:12ecdd0778e649b788738dc5fc9349742021-12-02T14:38:56ZMeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome10.1038/ncomms105522041-1723https://doaj.org/article/12ecdd0778e649b788738dc5fc9349742016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10552https://doaj.org/toc/2041-1723Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity.Derek J. C. TaiYen C. LiuWei L. HsuYun L. MaSin J. ChengShau Y. LiuEminy H. Y. LeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Derek J. C. Tai Yen C. Liu Wei L. Hsu Yun L. Ma Sin J. Cheng Shau Y. Liu Eminy H. Y. Lee MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
description	Post-translational modifications of methyl-CpG-binding protein 2 (MeCP2) are important for its function and dysfunction in Rett syndrome. Here, Tai et al. show a functional interaction between MeCP2 SUMOylation and phosphorylation in rodent behavior and synaptic plasticity.
format	article
author	Derek J. C. Tai Yen C. Liu Wei L. Hsu Yun L. Ma Sin J. Cheng Shau Y. Liu Eminy H. Y. Lee
author_facet	Derek J. C. Tai Yen C. Liu Wei L. Hsu Yun L. Ma Sin J. Cheng Shau Y. Liu Eminy H. Y. Lee
author_sort	Derek J. C. Tai
title	MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
title_short	MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
title_full	MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
title_fullStr	MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
title_full_unstemmed	MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome
title_sort	mecp2 sumoylation rescues mecp2-mutant-induced behavioural deficits in a mouse model of rett syndrome
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/12ecdd0778e649b788738dc5fc934974
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MeCP2 SUMOylation rescues Mecp2-mutant-induced behavioural deficits in a mouse model of Rett syndrome

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