Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos

Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos

Roughly 25% of mouse genes are embryonically lethal when knocked out, preventing the generation of viable mouse models. Here the authors use CRISPR-Cas9 to edit one blastomere of a two-cell embryo to generate viable chimeric mice.

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Bibliographic Details
Main Authors: Yi Wu, Jing Zhang, Boya Peng, Dan Tian, Dong Zhang, Yang Li, Xiaoyu Feng, Jinghao Liu, Jun Li, Teng Zhang, Xiaoyong Liu, Jing Lu, Baian Chen, Songlin Wang
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/131fc399bebb467090e5dd21ea95996a
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https://doaj.org/article/131fc399bebb467090e5dd21ea95996a

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