MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells

The Sodium/Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid follicular cells. Differentiated thyroid carcinomas (DTCs) usually preserve the functional expression of NIS, allowing the use of radioactive iodine (RAI) as the treatment of choice for metastatic diseas...

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Bibliographic Details
Main Authors: Márcia Faria, Rita Domingues, Maria João Bugalho, Paulo Matos, Ana Luísa Silva
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
NIS
Online Access:https://doaj.org/article/1326c3cbde884a68b08ba9f2e8b09ff1
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