MAPK Inhibition Requires Active RAC1 Signaling to Effectively Improve Iodide Uptake by Thyroid Follicular Cells
The Sodium/Iodide Symporter (NIS) is responsible for the active transport of iodide into thyroid follicular cells. Differentiated thyroid carcinomas (DTCs) usually preserve the functional expression of NIS, allowing the use of radioactive iodine (RAI) as the treatment of choice for metastatic diseas...
Guardado en:
Autores principales: | Márcia Faria, Rita Domingues, Maria João Bugalho, Paulo Matos, Ana Luísa Silva |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/1326c3cbde884a68b08ba9f2e8b09ff1 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Analysis of NIS Plasma Membrane Interactors Discloses Key Regulation by a SRC/RAC1/PAK1/PIP5K/EZRIN Pathway with Potential Implications for Radioiodine Re-Sensitization Therapy in Thyroid Cancer
por: Márcia Faria, et al.
Publicado: (2021) -
Novel Inhibitor-Based Therapies for Thyroid Cancer—An Update
por: Maciej Ratajczak, et al.
Publicado: (2021) -
FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
por: Mariana Cooke, et al.
Publicado: (2021) -
Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland
por: Huipan Liu, et al.
Publicado: (2021) -
Esophageal 99mTc-pertechnetate uptake mimicking an autonomous thyroid adenoma in a patient with subacute thyroiditis: a case report
por: Ahmad M Naser, et al.
Publicado: (2020)