Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

Modelling oral squamous cell carcinoma (OSCC) is a complex endeavour. Here, the authors provide a comprehensive analysis of an OSCC mouse model and show its mutational signatures mirror human OSCC, providing insights into OSCC clonal dynamics, the microenvironment and evolution.

Guardado en:

Detalles Bibliográficos
Autores principales:	Inês Sequeira, Mamunur Rashid, Inês M. Tomás, Marc J. Williams, Trevor A. Graham, David J. Adams, Alessandra Vigilante, Fiona M. Watt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13283850aaeb488c9ff3f4816f9ef00d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:13283850aaeb488c9ff3f4816f9ef00d
record_format	dspace
spelling	oai:doaj.org-article:13283850aaeb488c9ff3f4816f9ef00d2021-12-02T14:40:41ZGenomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology10.1038/s41467-020-19401-92041-1723https://doaj.org/article/13283850aaeb488c9ff3f4816f9ef00d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19401-9https://doaj.org/toc/2041-1723Modelling oral squamous cell carcinoma (OSCC) is a complex endeavour. Here, the authors provide a comprehensive analysis of an OSCC mouse model and show its mutational signatures mirror human OSCC, providing insights into OSCC clonal dynamics, the microenvironment and evolution.Inês SequeiraMamunur RashidInês M. TomásMarc J. WilliamsTrevor A. GrahamDavid J. AdamsAlessandra VigilanteFiona M. WattNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Inês Sequeira Mamunur Rashid Inês M. Tomás Marc J. Williams Trevor A. Graham David J. Adams Alessandra Vigilante Fiona M. Watt Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
description	Modelling oral squamous cell carcinoma (OSCC) is a complex endeavour. Here, the authors provide a comprehensive analysis of an OSCC mouse model and show its mutational signatures mirror human OSCC, providing insights into OSCC clonal dynamics, the microenvironment and evolution.
format	article
author	Inês Sequeira Mamunur Rashid Inês M. Tomás Marc J. Williams Trevor A. Graham David J. Adams Alessandra Vigilante Fiona M. Watt
author_facet	Inês Sequeira Mamunur Rashid Inês M. Tomás Marc J. Williams Trevor A. Graham David J. Adams Alessandra Vigilante Fiona M. Watt
author_sort	Inês Sequeira
title	Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
title_short	Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
title_full	Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
title_fullStr	Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
title_full_unstemmed	Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
title_sort	genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/13283850aaeb488c9ff3f4816f9ef00d
work_keys_str_mv	AT inessequeira genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT mamunurrashid genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT inesmtomas genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT marcjwilliams genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT trevoragraham genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT davidjadams genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT alessandravigilante genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology AT fionamwatt genomiclandscapeandclonalarchitectureofmouseoralsquamouscellcarcinomasdictatetumourecology
_version_	1718390156096962560

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

Ejemplares similares