Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

por Judit Espana-Agusti, Anne Warren, Su Kit Chew, David J. Adams, Athena Matakidou
Publicado 2017

Differentiation dynamics of mammary epithelial cells revealed by single-cell RNA sequencing

por Karsten Bach, Sara Pensa, Marta Grzelak, James Hadfield, David J. Adams, John C. Marioni, Walid T. Khaled
Publicado 2017

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

por Inês Sequeira, Mamunur Rashid, Inês M. Tomás, Marc J. Williams, Trevor A. Graham, David J. Adams, Alessandra Vigilante, Fiona M. Watt
Publicado 2020

Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia

por Emmanuelle Supper, Saskia Rudat, Vivek Iyer, Alastair Droop, Kim Wong, Jean-François Spinella, Patrick Thomas, Guy Sauvageau, David J. Adams, Chi C. Wong
Publicado 2021

A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis

por Paul Krimpenfort, Margriet Snoek, Jan-Paul Lambooij, Ji-Ying Song, Robin van der Weide, Rajith Bhaskaran, Hans Teunissen, David J. Adams, Elzo de Wit, Anton Berns
Publicado 2019

Germline MC1R status influences somatic mutation burden in melanoma

por Carla Daniela Robles-Espinoza, Nicola D. Roberts, Shuyang Chen, Finbarr P. Leacy, Ludmil B. Alexandrov, Natapol Pornputtapong, Ruth Halaban, Michael Krauthammer, Rutao Cui, D. Timothy Bishop, David J. Adams
Publicado 2016

Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML

por Silvia Basilico, Xiaonan Wang, Alison Kennedy, Konstantinos Tzelepis, George Giotopoulos, Sarah J. Kinston, Pedro M. Quiros, Kim Wong, David J. Adams, Larissa S. Carnevalli, Brian J. P. Huntly, George S. Vassiliou, Fernando J. Calero-Nieto, Berthold Göttgens
Publicado 2020

Insertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.

por Camille A Huser, Kathryn L Gilroy, Jeroen de Ridder, Anna Kilbey, Gillian Borland, Nancy Mackay, Alma Jenkins, Margaret Bell, Pawel Herzyk, Louise van der Weyden, David J Adams, Alistair G Rust, Ewan Cameron, James C Neil
Publicado 2014

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

por Louise van der Weyden, Victoria Harle, Gemma Turner, Victoria Offord, Vivek Iyer, Alastair Droop, Agnieszka Swiatkowska, Roy Rabbie, Andrew D. Campbell, Owen J. Sansom, Mercedes Pardo, Jyoti S. Choudhary, Ingrid Ferreira, Mark Tullett, Mark J. Arends, Anneliese O. Speak, David J. Adams
Publicado 2021

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

por Bidesh Mahata, Jhuma Pramanik, Louise van der Weyden, Krzysztof Polanski, Gozde Kar, Angela Riedel, Xi Chen, Nuno A. Fonseca, Kousik Kundu, Lia S. Campos, Edward Ryder, Graham Duddy, Izabela Walczak, Klaus Okkenhaug, David J. Adams, Jacqueline D. Shields, Sarah A. Teichmann
Publicado 2020

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity

por Joshua S. Wingerd, Christine A. Mozar, Christine A. Ussing, Swetha S. Murali, Yanni K.-Y. Chin, Ben Cristofori-Armstrong, Thomas Durek, John Gilchrist, Christopher W. Vaughan, Frank Bosmans, David J. Adams, Richard J. Lewis, Paul F. Alewood, Mehdi Mobli, Macdonald J. Christie, Lachlan D. Rash
Publicado 2017

Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis

por Stephan C. Collins, Anna Mikhaleva, Katarina Vrcelj, Valerie E. Vancollie, Christel Wagner, Nestor Demeure, Helen Whitley, Meghna Kannan, Rebecca Balz, Lauren F. E. Anthony, Andrew Edwards, Hervé Moine, Jacqueline K. White, David J. Adams, Alexandre Reymond, Christopher J. Lelliott, Caleb Webber, Binnaz Yalcin
Publicado 2019

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

por Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson
Publicado 2018

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance

por Matthew J. Sale, Kathryn Balmanno, Jayeta Saxena, Eiko Ozono, Katarzyna Wojdyla, Rebecca E. McIntyre, Rebecca Gilley, Anna Woroniuk, Karen D. Howarth, Gareth Hughes, Jonathan R. Dry, Mark J. Arends, Pilar Caro, David Oxley, Susan Ashton, David J. Adams, Julio Saez-Rodriguez, Paul D. Smith, Simon J. Cook
Publicado 2019

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma

por Jose Mario Gonzalez-Meljem, Scott Haston, Gabriela Carreno, John R. Apps, Sara Pozzi, Christina Stache, Grace Kaushal, Alex Virasami, Leonidas Panousopoulos, Seyedeh Neda Mousavy-Gharavy, Ana Guerrero, Mamunur Rashid, Nital Jani, Colin R. Goding, Thomas S. Jacques, David J. Adams, Jesus Gil, Cynthia L. Andoniadou, Juan Pedro Martinez-Barbera
Publicado 2017

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

por Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
Publicado 2019

Combinatorial CRISPR screen identifies fitness effects of gene paralogues

por Nicola A. Thompson, Marco Ranzani, Louise van der Weyden, Vivek Iyer, Victoria Offord, Alastair Droop, Fiona Behan, Emanuel Gonçalves, Anneliese Speak, Francesco Iorio, James Hewinson, Victoria Harle, Holly Robertson, Elizabeth Anderson, Beiyuan Fu, Fengtang Yang, Guido Zagnoli-Vieira, Phil Chapman, Martin Del Castillo Velasco-Herrera, Mathew J. Garnett, Stephen P. Jackson, David J. Adams
Publicado 2021

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

por Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin
Publicado 2014

Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

por Roy Rabbie, Naser Ansari-Pour, Oliver Cast, Doreen Lau, Francis Scott, Sarah J. Welsh, Christine Parkinson, Leila Khoja, Luiza Moore, Mark Tullett, Kim Wong, Ingrid Ferreira, Julia M. Martínez Gómez, Mitchell Levesque, Ferdia A. Gallagher, Alejandro Jiménez-Sánchez, Laura Riva, Martin L. Miller, Kieren Allinson, Peter J. Campbell, Pippa Corrie, David C. Wedge, David J. Adams
Publicado 2020

Common and distinct transcriptional signatures of mammalian embryonic lethality

por John E. Collins, Richard J. White, Nicole Staudt, Ian M. Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K. White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H. Geyer, Wolfgang J. Weninger, Antonella Galli, Myriam Hemberger, Derek L. Stemple, Elizabeth Robertson, James C. Smith, Timothy Mohun, David J. Adams, Elisabeth M. Busch-Nentwich
Publicado 2019