Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries

por Swee Hoe Ong, Yilong Li, Hiroko Koike-Yusa, Kosuke Yusa
Publicado 2017

Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions

por Oliver Thompson, Ferdinand von Meyenn, Zoe Hewitt, John Alexander, Andrew Wood, Richard Weightman, Sian Gregory, Felix Krueger, Simon Andrews, Ivana Barbaric, Paul J. Gokhale, Harry D. Moore, Wolf Reik, Marta Milo, Serena Nik-Zainal, Kosuke Yusa, Peter W. Andrews
Publicado 2020

Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

por Gabriele Picco, Elisabeth D. Chen, Luz Garcia Alonso, Fiona M. Behan, Emanuel Gonçalves, Graham Bignell, Angela Matchan, Beiyuan Fu, Ruby Banerjee, Elizabeth Anderson, Adam Butler, Cyril H. Benes, Ultan McDermott, David Dow, Francesco Iorio, Euan Stronach, Fengtang Yang, Kosuke Yusa, Julio Saez-Rodriguez, Mathew J. Garnett
Publicado 2019

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

por Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publicado 2018

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

por Gabriel Balmus, Domenic Pilger, Julia Coates, Mukerrem Demir, Matylda Sczaniecka-Clift, Ana C. Barros, Michael Woods, Beiyuan Fu, Fengtang Yang, Elisabeth Chen, Matthias Ostermaier, Tatjana Stankovic, Hannes Ponstingl, Mareike Herzog, Kosuke Yusa, Francisco Munoz Martinez, Stephen T. Durant, Yaron Galanty, Petra Beli, David J. Adams, Allan Bradley, Emmanouil Metzakopian, Josep V. Forment, Stephen P. Jackson
Publicado 2019

Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets

por Joshua M. Dempster, Clare Pacini, Sasha Pantel, Fiona M. Behan, Thomas Green, John Krill-Burger, Charlotte M. Beaver, Scott T. Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G. Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S. Boehm, Todd R. Golub, William C. Hahn, David E. Root, Mathew J. Garnett, Aviad Tsherniak, Francesco Iorio
Publicado 2019

SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4

por Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. Bannister, Roland Rad, Rab K. Prinjha, John C. Marioni, Brian Huntly, Jennifer Batson, Jonathan C. Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O. Bates, Kosuke Yusa, Tony Kouzarides, George S. Vassiliou
Publicado 2018