Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

Modelling oral squamous cell carcinoma (OSCC) is a complex endeavour. Here, the authors provide a comprehensive analysis of an OSCC mouse model and show its mutational signatures mirror human OSCC, providing insights into OSCC clonal dynamics, the microenvironment and evolution.

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Autores principales: Inês Sequeira, Mamunur Rashid, Inês M. Tomás, Marc J. Williams, Trevor A. Graham, David J. Adams, Alessandra Vigilante, Fiona M. Watt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/13283850aaeb488c9ff3f4816f9ef00d
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