Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.

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Detalles Bibliográficos
Autores principales: Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O. Collins, Sindhu Naik, Claire M. Murzeau, Pei-Li Tseng, Kai S. Erdmann
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/132fc68029dd4842a59ec193c7636a33
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