Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.

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Autores principales:	Shruti Sharma, Antonio Carmona, Agnieszka Skowronek, Fangyan Yu, Mark O. Collins, Sindhu Naik, Claire M. Murzeau, Pei-Li Tseng, Kai S. Erdmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/132fc68029dd4842a59ec193c7636a33
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spelling	oai:doaj.org-article:132fc68029dd4842a59ec193c7636a332021-12-02T17:31:37ZApoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD9510.1038/s41467-019-11025-y2041-1723https://doaj.org/article/132fc68029dd4842a59ec193c7636a332019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11025-yhttps://doaj.org/toc/2041-1723Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.Shruti SharmaAntonio CarmonaAgnieszka SkowronekFangyan YuMark O. CollinsSindhu NaikClaire M. MurzeauPei-Li TsengKai S. ErdmannNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
description	Fas is a death receptor that regulates apoptosis in many cell types and is downregulated on the cell surface in many cancers. Here, Sharma et al. show that endosome associated trafficking regulator ENTR1 regulates delivery of Fas to lysosomes, thereby controlling its degradation and signalling.
format	article
author	Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann
author_facet	Shruti Sharma Antonio Carmona Agnieszka Skowronek Fangyan Yu Mark O. Collins Sindhu Naik Claire M. Murzeau Pei-Li Tseng Kai S. Erdmann
author_sort	Shruti Sharma
title	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_short	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_full	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_fullStr	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_full_unstemmed	Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95
title_sort	apoptotic signalling targets the post-endocytic sorting machinery of the death receptor fas/cd95
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/132fc68029dd4842a59ec193c7636a33
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Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95

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