Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGene relationships mediated by chromosomal interacti...

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Autores principales: David Z. Pan, Kristina M. Garske, Marcus Alvarez, Yash V. Bhagat, James Boocock, Elina Nikkola, Zong Miao, Chelsea K. Raulerson, Rita M. Cantor, Mete Civelek, Craig A. Glastonbury, Kerrin S. Small, Michael Boehnke, Aldons J. Lusis, Janet S. Sinsheimer, Karen L. Mohlke, Markku Laakso, Päivi Pajukanta, Arthur Ko
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Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/133629e0a6304f2f8d3499574a04d269
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spelling oai:doaj.org-article:133629e0a6304f2f8d3499574a04d2692021-12-02T17:31:44ZIntegration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS10.1038/s41467-018-03554-92041-1723https://doaj.org/article/133629e0a6304f2f8d3499574a04d2692018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03554-9https://doaj.org/toc/2041-1723GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGene relationships mediated by chromosomal interactions.David Z. PanKristina M. GarskeMarcus AlvarezYash V. BhagatJames BoocockElina NikkolaZong MiaoChelsea K. RaulersonRita M. CantorMete CivelekCraig A. GlastonburyKerrin S. SmallMichael BoehnkeAldons J. LusisJanet S. SinsheimerKaren L. MohlkeMarkku LaaksoPäivi PajukantaArthur KoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
David Z. Pan
Kristina M. Garske
Marcus Alvarez
Yash V. Bhagat
James Boocock
Elina Nikkola
Zong Miao
Chelsea K. Raulerson
Rita M. Cantor
Mete Civelek
Craig A. Glastonbury
Kerrin S. Small
Michael Boehnke
Aldons J. Lusis
Janet S. Sinsheimer
Karen L. Mohlke
Markku Laakso
Päivi Pajukanta
Arthur Ko
Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
description GWAS have identified numerous genetic loci for BMI and related traits. Here, Pan et al. generate Promoter Capture Hi-C data for human white adipocytes and integrate these with data of transcription factor motifs, RNA-seq and GWAS to identify eQTL-eGene relationships mediated by chromosomal interactions.
format article
author David Z. Pan
Kristina M. Garske
Marcus Alvarez
Yash V. Bhagat
James Boocock
Elina Nikkola
Zong Miao
Chelsea K. Raulerson
Rita M. Cantor
Mete Civelek
Craig A. Glastonbury
Kerrin S. Small
Michael Boehnke
Aldons J. Lusis
Janet S. Sinsheimer
Karen L. Mohlke
Markku Laakso
Päivi Pajukanta
Arthur Ko
author_facet David Z. Pan
Kristina M. Garske
Marcus Alvarez
Yash V. Bhagat
James Boocock
Elina Nikkola
Zong Miao
Chelsea K. Raulerson
Rita M. Cantor
Mete Civelek
Craig A. Glastonbury
Kerrin S. Small
Michael Boehnke
Aldons J. Lusis
Janet S. Sinsheimer
Karen L. Mohlke
Markku Laakso
Päivi Pajukanta
Arthur Ko
author_sort David Z. Pan
title Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
title_short Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
title_full Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
title_fullStr Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
title_full_unstemmed Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS
title_sort integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from gwas
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/133629e0a6304f2f8d3499574a04d269
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