Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats

Abstract Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids. Present SCS therapies are characterized by the delivery of constant stimulation in the form of trains of tonic pulses (TPs). We tested the hypothesis that mod...

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Autores principales: Muhammad M. Edhi, Lonne Heijmans, Kevin N. Vanent, Kiernan Bloye, Amanda Baanante, Ki-Soo Jeong, Jason Leung, Changfang Zhu, Rosana Esteller, Carl Y. Saab
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/13407e805180457ca6392ef3cb28ac16
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