Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats

Abstract Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids. Present SCS therapies are characterized by the delivery of constant stimulation in the form of trains of tonic pulses (TPs). We tested the hypothesis that mod...

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Autores principales:	Muhammad M. Edhi, Lonne Heijmans, Kevin N. Vanent, Kiernan Bloye, Amanda Baanante, Ki-Soo Jeong, Jason Leung, Changfang Zhu, Rosana Esteller, Carl Y. Saab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/13407e805180457ca6392ef3cb28ac16
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spelling	oai:doaj.org-article:13407e805180457ca6392ef3cb28ac162021-12-02T16:09:10ZTime-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats10.1038/s41598-020-77212-w2045-2322https://doaj.org/article/13407e805180457ca6392ef3cb28ac162020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77212-whttps://doaj.org/toc/2045-2322Abstract Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids. Present SCS therapies are characterized by the delivery of constant stimulation in the form of trains of tonic pulses (TPs). We tested the hypothesis that modulated SCS using novel time-dynamic pulses (TDPs) leads to improved analgesia and compared the effects of SCS using conventional TPs and a collection of TDPs in a rat model of neuropathic pain according to a longitudinal, double-blind, and crossover design. We tested the effects of the following SCS patterns on paw withdrawal threshold and resting state EEG theta power as a biomarker of spontaneous pain: Tonic (conventional), amplitude modulation, pulse width modulation, sinusoidal rate modulation, and stochastic rate modulation. Results demonstrated that under the parameter settings tested in this study, all tested patterns except pulse width modulation, significantly reversed mechanical hypersensitivity, with stochastic rate modulation achieving the highest efficacy, followed by the sinusoidal rate modulation. The anti-nociceptive effects of sinusoidal rate modulation on EEG outlasted SCS duration on the behavioral and EEG levels. These results suggest that TDP modulation may improve clinical outcomes by reducing pain intensity and possibly improving the sensory experience.Muhammad M. EdhiLonne HeijmansKevin N. VanentKiernan BloyeAmanda BaananteKi-Soo JeongJason LeungChangfang ZhuRosana EstellerCarl Y. SaabNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Muhammad M. Edhi Lonne Heijmans Kevin N. Vanent Kiernan Bloye Amanda Baanante Ki-Soo Jeong Jason Leung Changfang Zhu Rosana Esteller Carl Y. Saab Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
description	Abstract Enhancing the efficacy of spinal cord stimulation (SCS) is needed to alleviate the burden of chronic pain and dependence on opioids. Present SCS therapies are characterized by the delivery of constant stimulation in the form of trains of tonic pulses (TPs). We tested the hypothesis that modulated SCS using novel time-dynamic pulses (TDPs) leads to improved analgesia and compared the effects of SCS using conventional TPs and a collection of TDPs in a rat model of neuropathic pain according to a longitudinal, double-blind, and crossover design. We tested the effects of the following SCS patterns on paw withdrawal threshold and resting state EEG theta power as a biomarker of spontaneous pain: Tonic (conventional), amplitude modulation, pulse width modulation, sinusoidal rate modulation, and stochastic rate modulation. Results demonstrated that under the parameter settings tested in this study, all tested patterns except pulse width modulation, significantly reversed mechanical hypersensitivity, with stochastic rate modulation achieving the highest efficacy, followed by the sinusoidal rate modulation. The anti-nociceptive effects of sinusoidal rate modulation on EEG outlasted SCS duration on the behavioral and EEG levels. These results suggest that TDP modulation may improve clinical outcomes by reducing pain intensity and possibly improving the sensory experience.
format	article
author	Muhammad M. Edhi Lonne Heijmans Kevin N. Vanent Kiernan Bloye Amanda Baanante Ki-Soo Jeong Jason Leung Changfang Zhu Rosana Esteller Carl Y. Saab
author_facet	Muhammad M. Edhi Lonne Heijmans Kevin N. Vanent Kiernan Bloye Amanda Baanante Ki-Soo Jeong Jason Leung Changfang Zhu Rosana Esteller Carl Y. Saab
author_sort	Muhammad M. Edhi
title	Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
title_short	Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
title_full	Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
title_fullStr	Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
title_full_unstemmed	Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
title_sort	time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/13407e805180457ca6392ef3cb28ac16
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Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats

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