An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping
Hamada et al. engineer and utilise a channelrhodopsin-2 variant that is localized to presynaptic axon terminals. They demonstrate its use for circuitry mapping in vivo and thus provide a useful tool for future optogenetic experiments
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Nature Portfolio
2021
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oai:doaj.org-article:13bb96c2e73745bfae399a7b886c98d72021-12-02T15:51:05ZAn engineered channelrhodopsin optimized for axon terminal activation and circuit mapping10.1038/s42003-021-01977-72399-3642https://doaj.org/article/13bb96c2e73745bfae399a7b886c98d72021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01977-7https://doaj.org/toc/2399-3642Hamada et al. engineer and utilise a channelrhodopsin-2 variant that is localized to presynaptic axon terminals. They demonstrate its use for circuitry mapping in vivo and thus provide a useful tool for future optogenetic experimentsShun HamadaMasashi NagaseTomohiko YoshizawaAkari HagiwaraYoshikazu IsomuraAyako M. WatabeToshihisa OhtsukaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Shun Hamada Masashi Nagase Tomohiko Yoshizawa Akari Hagiwara Yoshikazu Isomura Ayako M. Watabe Toshihisa Ohtsuka An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| description |
Hamada et al. engineer and utilise a channelrhodopsin-2 variant that is localized to presynaptic axon terminals. They demonstrate its use for circuitry mapping in vivo and thus provide a useful tool for future optogenetic experiments |
| format |
article |
| author |
Shun Hamada Masashi Nagase Tomohiko Yoshizawa Akari Hagiwara Yoshikazu Isomura Ayako M. Watabe Toshihisa Ohtsuka |
| author_facet |
Shun Hamada Masashi Nagase Tomohiko Yoshizawa Akari Hagiwara Yoshikazu Isomura Ayako M. Watabe Toshihisa Ohtsuka |
| author_sort |
Shun Hamada |
| title |
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| title_short |
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| title_full |
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| title_fullStr |
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| title_full_unstemmed |
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| title_sort |
engineered channelrhodopsin optimized for axon terminal activation and circuit mapping |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/13bb96c2e73745bfae399a7b886c98d7 |
| work_keys_str_mv |
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1718385614151221248 |