High Plasma Lipid Levels Reduce Efficacy of Adenovirus-Mediated Gene Therapy
Abstract Adenoviruses are very efficient vectors for delivering therapeutic genes in preclinical and clinical trials. However, randomized controlled human trials have often been lacking clear clinically relevant results. We hypothesized that high lipid levels and specific lipoproteins could signific...
Saved in:
Main Authors: | A. M. Kivelä, J. Huusko, E. Gurzeler, A. Laine, M. H. Dijkstra, G. Dragneva, C. B. F. Andersen, S. K. Moestrup, S. Ylä-Herttuala |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/13eec640ea744d0e8b268a995fb998d0 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.
by: Erika Gurzeler, et al.
Published: (2021) -
SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice
by: Erika Gurzeler, et al.
Published: (2021) -
A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition.
by: Neda Bagheri, et al.
Published: (2011) -
Epigenetic upregulation of endogenous VEGF-A reduces myocardial infarct size in mice.
by: Mikko P Turunen, et al.
Published: (2014) -
Systemic therapy for cervical cancer with potentially regulatable oncolytic adenoviruses.
by: Anna Kanerva, et al.
Published: (2008)