Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes

Many genes of functional and clinical significance are highly polymorphic and experience structural alterations. Here, Numanagić et al. develop Aldy, a computational tool for resolving the copy number and the sequence content of each copy of a gene by analyzing whole or targeted genome sequencing da...

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Autores principales:	Ibrahim Numanagić, Salem Malikić, Michael Ford, Xiang Qin, Lorraine Toji, Milan Radovich, Todd C. Skaar, Victoria M. Pratt, Bonnie Berger, Steve Scherer, S. Cenk Sahinalp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/13fe87a202d640f58073d217f30b3a93
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spelling	oai:doaj.org-article:13fe87a202d640f58073d217f30b3a932021-12-02T16:56:37ZAllelic decomposition and exact genotyping of highly polymorphic and structurally variant genes10.1038/s41467-018-03273-12041-1723https://doaj.org/article/13fe87a202d640f58073d217f30b3a932018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03273-1https://doaj.org/toc/2041-1723Many genes of functional and clinical significance are highly polymorphic and experience structural alterations. Here, Numanagić et al. develop Aldy, a computational tool for resolving the copy number and the sequence content of each copy of a gene by analyzing whole or targeted genome sequencing data.Ibrahim NumanagićSalem MalikićMichael FordXiang QinLorraine TojiMilan RadovichTodd C. SkaarVictoria M. PrattBonnie BergerSteve SchererS. Cenk SahinalpNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ibrahim Numanagić Salem Malikić Michael Ford Xiang Qin Lorraine Toji Milan Radovich Todd C. Skaar Victoria M. Pratt Bonnie Berger Steve Scherer S. Cenk Sahinalp Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
description	Many genes of functional and clinical significance are highly polymorphic and experience structural alterations. Here, Numanagić et al. develop Aldy, a computational tool for resolving the copy number and the sequence content of each copy of a gene by analyzing whole or targeted genome sequencing data.
format	article
author	Ibrahim Numanagić Salem Malikić Michael Ford Xiang Qin Lorraine Toji Milan Radovich Todd C. Skaar Victoria M. Pratt Bonnie Berger Steve Scherer S. Cenk Sahinalp
author_facet	Ibrahim Numanagić Salem Malikić Michael Ford Xiang Qin Lorraine Toji Milan Radovich Todd C. Skaar Victoria M. Pratt Bonnie Berger Steve Scherer S. Cenk Sahinalp
author_sort	Ibrahim Numanagić
title	Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
title_short	Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
title_full	Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
title_fullStr	Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
title_full_unstemmed	Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
title_sort	allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/13fe87a202d640f58073d217f30b3a93
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Allelic decomposition and exact genotyping of highly polymorphic and structurally variant genes

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