Clathrin adapters AP-1 and GGA2 support expression of epidermal growth factor receptor for cell growth

Abstract The role of Golgi/endosome-localized clathrin adapters in the maintenance of steady-state cell surface epidermal growth factor receptor (EGFR) is not well known. Here, we show that EGFR associates preferentially with both AP-1 and GGA2 in vitro. AP-1 depletion caused a reduction in the EGFR...

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Autores principales: Takefumi Uemura, Takehiro Suzuki, Naoshi Dohmae, Satoshi Waguri
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
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Acceso en línea:https://doaj.org/article/141cef8827ce44c189674d485234760b
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