Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences

Abstract Behavioral automatization usually makes us more efficient and less error-prone, but may also foster dysfunctional behavior like alcohol abuse. Yet, it has remained unclear whether alcohol itself causes the shift from controlled to habitual behavior commonly observed in alcohol use disorder...

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Autores principales:	Antje Opitz, Filippo Ghin, Jan Hubert, Joris C. Verster, Christian Beste, Ann-Kathrin Stock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/143c82c9e6b341999d5bd385b8cda801
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spelling	oai:doaj.org-article:143c82c9e6b341999d5bd385b8cda8012021-12-02T17:41:07ZAlcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences10.1038/s41598-021-90803-52045-2322https://doaj.org/article/143c82c9e6b341999d5bd385b8cda8012021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90803-5https://doaj.org/toc/2045-2322Abstract Behavioral automatization usually makes us more efficient and less error-prone, but may also foster dysfunctional behavior like alcohol abuse. Yet, it has remained unclear whether alcohol itself causes the shift from controlled to habitual behavior commonly observed in alcohol use disorder (AUD). We thus investigated how the acute and post-acute effects of binge drinking affect the automatization of motor response sequences and the execution of automated vs. controlled motor response sequences. N = 70 healthy young men performed a newly developed automatization paradigm once sober and once after binge drinking (half of them intoxicated and half of them hungover). While we found no significant effects of alcohol hangover, acute intoxication (~ 1.2 ‰) had two dissociable effects: Firstly, it impaired the automatization of complex motor response sequence execution. Secondly, it eliminated learning effects in response selection and pre-motor planning processes. The results suggest that alcohol hangover did not affect controlled or automated processes, and disprove the assumption that alcohol intoxication generally spares or facilitates motor response sequence automatization. As these effects could be specific to the investigated explicit learning context, acute intoxication might potentially still improve the execution of pre-existing automatisms and/or the implicit acquisition of motor response sequence automatisms.Antje OpitzFilippo GhinJan HubertJoris C. VersterChristian BesteAnn-Kathrin StockNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Antje Opitz Filippo Ghin Jan Hubert Joris C. Verster Christian Beste Ann-Kathrin Stock Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
description	Abstract Behavioral automatization usually makes us more efficient and less error-prone, but may also foster dysfunctional behavior like alcohol abuse. Yet, it has remained unclear whether alcohol itself causes the shift from controlled to habitual behavior commonly observed in alcohol use disorder (AUD). We thus investigated how the acute and post-acute effects of binge drinking affect the automatization of motor response sequences and the execution of automated vs. controlled motor response sequences. N = 70 healthy young men performed a newly developed automatization paradigm once sober and once after binge drinking (half of them intoxicated and half of them hungover). While we found no significant effects of alcohol hangover, acute intoxication (~ 1.2 ‰) had two dissociable effects: Firstly, it impaired the automatization of complex motor response sequence execution. Secondly, it eliminated learning effects in response selection and pre-motor planning processes. The results suggest that alcohol hangover did not affect controlled or automated processes, and disprove the assumption that alcohol intoxication generally spares or facilitates motor response sequence automatization. As these effects could be specific to the investigated explicit learning context, acute intoxication might potentially still improve the execution of pre-existing automatisms and/or the implicit acquisition of motor response sequence automatisms.
format	article
author	Antje Opitz Filippo Ghin Jan Hubert Joris C. Verster Christian Beste Ann-Kathrin Stock
author_facet	Antje Opitz Filippo Ghin Jan Hubert Joris C. Verster Christian Beste Ann-Kathrin Stock
author_sort	Antje Opitz
title	Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
title_short	Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
title_full	Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
title_fullStr	Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
title_full_unstemmed	Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
title_sort	alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/143c82c9e6b341999d5bd385b8cda801
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Alcohol intoxication, but not hangover, differentially impairs learning and automatization of complex motor response sequences

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