Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan

Abstract The intrinsic aerobic capacity of an organism is thought to play a role in aging and longevity. Maximal respiratory rate capacity, a metabolic performance measure, is one of the best predictors of cardiovascular- and all-cause mortality. Rats selectively bred for high-(HCR) vs. low-(LCR) in...

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Autores principales: Miguel A. Aon, Sonia Cortassa, Magdalena Juhaszova, José A. González-Reyes, Miguel Calvo-Rubio, José M. Villalba, Andrew D. Lachance, Bruce D. Ziman, Sarah J. Mitchell, Kelsey N. Murt, Jessie E. C. Axsom, Irene Alfaras, Steven L. Britton, Lauren G. Koch, Rafael de Cabo, Edward G. Lakatta, Steven J. Sollott
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/14634003ef5e447c891b439fccd94408
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