A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

Existence of 150–170 serologically distinct human rhinoviruses (HRV) has hampered vaccine development for this human pathogen. Here, the authors show that a prime-boost regimen with an inactivated 50-valent HRV vaccine induces neutralizing antibody responses to diverse HRV serotypes in rhesus macaqu...

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Autores principales: Sujin Lee, Minh Trang Nguyen, Michael G. Currier, Joe B. Jenkins, Elizabeth A. Strobert, Adriana E. Kajon, Ranjna Madan-Lala, Yury A. Bochkov, James E. Gern, Krishnendu Roy, Xiaoyan Lu, Dean D. Erdman, Paul Spearman, Martin L. Moore
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/1472e837dd8b4360bb69aa5950313aef
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spelling oai:doaj.org-article:1472e837dd8b4360bb69aa5950313aef2021-12-02T16:56:47ZA polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques10.1038/ncomms128382041-1723https://doaj.org/article/1472e837dd8b4360bb69aa5950313aef2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12838https://doaj.org/toc/2041-1723Existence of 150–170 serologically distinct human rhinoviruses (HRV) has hampered vaccine development for this human pathogen. Here, the authors show that a prime-boost regimen with an inactivated 50-valent HRV vaccine induces neutralizing antibody responses to diverse HRV serotypes in rhesus macaques.Sujin LeeMinh Trang NguyenMichael G. CurrierJoe B. JenkinsElizabeth A. StrobertAdriana E. KajonRanjna Madan-LalaYury A. BochkovJames E. GernKrishnendu RoyXiaoyan LuDean D. ErdmanPaul SpearmanMartin L. MooreNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sujin Lee
Minh Trang Nguyen
Michael G. Currier
Joe B. Jenkins
Elizabeth A. Strobert
Adriana E. Kajon
Ranjna Madan-Lala
Yury A. Bochkov
James E. Gern
Krishnendu Roy
Xiaoyan Lu
Dean D. Erdman
Paul Spearman
Martin L. Moore
A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
description Existence of 150–170 serologically distinct human rhinoviruses (HRV) has hampered vaccine development for this human pathogen. Here, the authors show that a prime-boost regimen with an inactivated 50-valent HRV vaccine induces neutralizing antibody responses to diverse HRV serotypes in rhesus macaques.
format article
author Sujin Lee
Minh Trang Nguyen
Michael G. Currier
Joe B. Jenkins
Elizabeth A. Strobert
Adriana E. Kajon
Ranjna Madan-Lala
Yury A. Bochkov
James E. Gern
Krishnendu Roy
Xiaoyan Lu
Dean D. Erdman
Paul Spearman
Martin L. Moore
author_facet Sujin Lee
Minh Trang Nguyen
Michael G. Currier
Joe B. Jenkins
Elizabeth A. Strobert
Adriana E. Kajon
Ranjna Madan-Lala
Yury A. Bochkov
James E. Gern
Krishnendu Roy
Xiaoyan Lu
Dean D. Erdman
Paul Spearman
Martin L. Moore
author_sort Sujin Lee
title A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
title_short A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
title_full A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
title_fullStr A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
title_full_unstemmed A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
title_sort polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/1472e837dd8b4360bb69aa5950313aef
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