The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.

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Autores principales:	Sebastian Kaiser, Florian Sauer, Caroline Kisker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/147d31ce692b44a8aba126cc52fb6e05
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spelling	oai:doaj.org-article:147d31ce692b44a8aba126cc52fb6e052021-12-02T15:38:45ZThe structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism10.1038/ncomms159072041-1723https://doaj.org/article/147d31ce692b44a8aba126cc52fb6e052017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15907https://doaj.org/toc/2041-1723RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.Sebastian KaiserFlorian SauerCaroline KiskerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sebastian Kaiser Florian Sauer Caroline Kisker The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
description	RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.
format	article
author	Sebastian Kaiser Florian Sauer Caroline Kisker
author_facet	Sebastian Kaiser Florian Sauer Caroline Kisker
author_sort	Sebastian Kaiser
title	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_short	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_full	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_fullStr	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_full_unstemmed	The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
title_sort	structural and functional characterization of human recq4 reveals insights into its helicase mechanism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/147d31ce692b44a8aba126cc52fb6e05
work_keys_str_mv	AT sebastiankaiser thestructuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism AT floriansauer thestructuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism AT carolinekisker thestructuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism AT sebastiankaiser structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism AT floriansauer structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism AT carolinekisker structuralandfunctionalcharacterizationofhumanrecq4revealsinsightsintoitshelicasemechanism
_version_	1718386095156101120

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

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