Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer

Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer

The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.

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Autores principales: Jianzhen Lin, Xinxin Peng, Kun Dong, Junyu Long, Xuejiao Guo, Hongyue Li, Yi Bai, Xu Yang, Dongxu Wang, Xin Lu, Yilei Mao, Xinting Sang, Xuwo Ji, Haitao Zhao, Han Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/148932c71cdc4be3a5257b88f4baf168
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spelling oai:doaj.org-article:148932c71cdc4be3a5257b88f4baf1682021-12-02T17:06:12ZGenomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer10.1038/s41467-021-25012-92041-1723https://doaj.org/article/148932c71cdc4be3a5257b88f4baf1682021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25012-9https://doaj.org/toc/2041-1723The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.Jianzhen LinXinxin PengKun DongJunyu LongXuejiao GuoHongyue LiYi BaiXu YangDongxu WangXin LuYilei MaoXinting SangXuwo JiHaitao ZhaoHan LiangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jianzhen Lin
Xinxin Peng
Kun Dong
Junyu Long
Xuejiao Guo
Hongyue Li
Yi Bai
Xu Yang
Dongxu Wang
Xin Lu
Yilei Mao
Xinting Sang
Xuwo Ji
Haitao Zhao
Han Liang
Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
description The progression from biliary tract intraepithelial neoplasia (BilIN) to gallbladder carcinoma (GBC) remains unclear. Here the authors use genomics to analyze coexisting GBC lesions, low-grade and high-grade BilINs, revealing two distinct evolutionary paths for GBC development.
format article
author Jianzhen Lin
Xinxin Peng
Kun Dong
Junyu Long
Xuejiao Guo
Hongyue Li
Yi Bai
Xu Yang
Dongxu Wang
Xin Lu
Yilei Mao
Xinting Sang
Xuwo Ji
Haitao Zhao
Han Liang
author_facet Jianzhen Lin
Xinxin Peng
Kun Dong
Junyu Long
Xuejiao Guo
Hongyue Li
Yi Bai
Xu Yang
Dongxu Wang
Xin Lu
Yilei Mao
Xinting Sang
Xuwo Ji
Haitao Zhao
Han Liang
author_sort Jianzhen Lin
title Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
title_short Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
title_full Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
title_fullStr Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
title_full_unstemmed Genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
title_sort genomic characterization of co-existing neoplasia and carcinoma lesions reveals distinct evolutionary paths of gallbladder cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/148932c71cdc4be3a5257b88f4baf168
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