NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription

Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear receptors to drive gene expression.

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Autores principales:	Natalia Fili, Yukti Hari-Gupta, Ália dos Santos, Alexander Cook, Simon Poland, Simon M. Ameer-Beg, Maddy Parsons, Christopher P. Toseland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14b2334ce9e44248852b7f5d9eafede6
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spelling	oai:doaj.org-article:14b2334ce9e44248852b7f5d9eafede62021-12-02T14:42:33ZNDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription10.1038/s41467-017-02050-w2041-1723https://doaj.org/article/14b2334ce9e44248852b7f5d9eafede62017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02050-whttps://doaj.org/toc/2041-1723Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear receptors to drive gene expression.Natalia FiliYukti Hari-GuptaÁlia dos SantosAlexander CookSimon PolandSimon M. Ameer-BegMaddy ParsonsChristopher P. ToselandNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Natalia Fili Yukti Hari-Gupta Ália dos Santos Alexander Cook Simon Poland Simon M. Ameer-Beg Maddy Parsons Christopher P. Toseland NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
description	Myosin VI (MVI) is known to interact with RNA Polymerase II and to play non-cytoplasmic roles in cells. Here, the authors provide evidence that the transcription co-activator NDP52 regulates MVI binding to DNA and that MVI interacts with nuclear receptors to drive gene expression.
format	article
author	Natalia Fili Yukti Hari-Gupta Ália dos Santos Alexander Cook Simon Poland Simon M. Ameer-Beg Maddy Parsons Christopher P. Toseland
author_facet	Natalia Fili Yukti Hari-Gupta Ália dos Santos Alexander Cook Simon Poland Simon M. Ameer-Beg Maddy Parsons Christopher P. Toseland
author_sort	Natalia Fili
title	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
title_short	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
title_full	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
title_fullStr	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
title_full_unstemmed	NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription
title_sort	ndp52 activates nuclear myosin vi to enhance rna polymerase ii transcription
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/14b2334ce9e44248852b7f5d9eafede6
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NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription

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