Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen, representing a simple approach to synthetic vacci...

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Autores principales: Felix Broecker, Jonas Hanske, Christopher E. Martin, Ju Yuel Baek, Annette Wahlbrink, Felix Wojcik, Laura Hartmann, Christoph Rademacher, Chakkumkal Anish, Peter H. Seeberger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/14c948723fd84a6ab537dce51dcba054
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