Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen, representing a simple approach to synthetic vacci...

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Autores principales:	Felix Broecker, Jonas Hanske, Christopher E. Martin, Ju Yuel Baek, Annette Wahlbrink, Felix Wojcik, Laura Hartmann, Christoph Rademacher, Chakkumkal Anish, Peter H. Seeberger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/14c948723fd84a6ab537dce51dcba054
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spelling	oai:doaj.org-article:14c948723fd84a6ab537dce51dcba0542021-12-02T14:38:57ZMultivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans10.1038/ncomms112242041-1723https://doaj.org/article/14c948723fd84a6ab537dce51dcba0542016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11224https://doaj.org/toc/2041-1723Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen, representing a simple approach to synthetic vaccine production.Felix BroeckerJonas HanskeChristopher E. MartinJu Yuel BaekAnnette WahlbrinkFelix WojcikLaura HartmannChristoph RademacherChakkumkal AnishPeter H. SeebergerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felix Broecker Jonas Hanske Christopher E. Martin Ju Yuel Baek Annette Wahlbrink Felix Wojcik Laura Hartmann Christoph Rademacher Chakkumkal Anish Peter H. Seeberger Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
description	Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen, representing a simple approach to synthetic vaccine production.
format	article
author	Felix Broecker Jonas Hanske Christopher E. Martin Ju Yuel Baek Annette Wahlbrink Felix Wojcik Laura Hartmann Christoph Rademacher Chakkumkal Anish Peter H. Seeberger
author_facet	Felix Broecker Jonas Hanske Christopher E. Martin Ju Yuel Baek Annette Wahlbrink Felix Wojcik Laura Hartmann Christoph Rademacher Chakkumkal Anish Peter H. Seeberger
author_sort	Felix Broecker
title	Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
title_short	Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
title_full	Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
title_fullStr	Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
title_full_unstemmed	Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
title_sort	multivalent display of minimal clostridium difficile glycan epitopes mimics antigenic properties of larger glycans
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/14c948723fd84a6ab537dce51dcba054
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Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

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