Cell-cycle-independent transitions in temporal identity of mammalian neural progenitor cells

The molecular mechanisms determining the temporal identity patterns of self-renewing progenitors during cerebral development are largely unclear. Here, using single cell transcriptome analyses, the authors find progenitor temporal identity arises independent of cell-cycle progression and Notch activ...

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Bibliographic Details
Main Authors: Mayumi Okamoto, Takaki Miyata, Daijiro Konno, Hiroki R. Ueda, Takeya Kasukawa, Mitsuhiro Hashimoto, Fumio Matsuzaki, Ayano Kawaguchi
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/14d86c76d9cd4db3ae8082859d9eaad4
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