0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop

Abstract DNA-damaging agents have been used in cancer chemotherapy for a long history. Unfortunately, chemotherapeutic treatment strategies against hepatocellular carcinoma (HCC) are still ineffective. We screened a novel DNA-damaging compound, designated as 0404, by using time-dependent cellular re...

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Bibliographic Details
Main Authors: Caixia Xia, Liyan Shui, Guohua Lou, Bingjue Ye, Wei Zhu, Jing Wang, Shanshan Wu, Xiao Xu, Long Mao, Wanhong Xu, Zhi Chen, Yanning Liu, Min Zheng
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/150068b23f294e5daa5fe3ae76c36ef2
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