Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

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Detalles Bibliográficos
Autores principales: Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba
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Internet

https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba

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