Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.

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Autores principales:	Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba
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spelling	oai:doaj.org-article:15032712babd4934b8cf9987f86cc0ba2021-12-02T14:42:25ZHepcidin is regulated by promoter-associated histone acetylation and HDAC310.1038/s41467-017-00500-z2041-1723https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00500-zhttps://doaj.org/toc/2041-1723Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.Sant-Rayn PasrichaPei Jin LimTiago L. DuarteCarla CasuDorenda OosterhuisKatarzyna Mleczko-SaneckaMaria SuciuAna Rita Da SilvaKinda Al-HouraniJoão ArezesKirsty McHughSarah GoodingJoe N. FrostKatherine WrayAna SantosGraça PortoEmmanouela RepapiNicki GraySimon J. DraperNeil AshleyElizabeth SoilleuxPeter OlingaMartina U. MuckenthalerJim R. HughesStefano RivellaThomas A. MilneAndrew E. ArmitageHal DrakesmithNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
description	Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.
format	article
author	Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith
author_facet	Sant-Rayn Pasricha Pei Jin Lim Tiago L. Duarte Carla Casu Dorenda Oosterhuis Katarzyna Mleczko-Sanecka Maria Suciu Ana Rita Da Silva Kinda Al-Hourani João Arezes Kirsty McHugh Sarah Gooding Joe N. Frost Katherine Wray Ana Santos Graça Porto Emmanouela Repapi Nicki Gray Simon J. Draper Neil Ashley Elizabeth Soilleux Peter Olinga Martina U. Muckenthaler Jim R. Hughes Stefano Rivella Thomas A. Milne Andrew E. Armitage Hal Drakesmith
author_sort	Sant-Rayn Pasricha
title	Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
title_short	Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
title_full	Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
title_fullStr	Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
title_full_unstemmed	Hepcidin is regulated by promoter-associated histone acetylation and HDAC3
title_sort	hepcidin is regulated by promoter-associated histone acetylation and hdac3
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/15032712babd4934b8cf9987f86cc0ba
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Hepcidin is regulated by promoter-associated histone acetylation and HDAC3

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